Time- and Concentration-Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in ALL Cells

Acute lymphoblastic leukemia (ALL) is a rapidly growing aggressive cancer of White Blood Cells (WBC) that mostly originates from bone morrow and is the most prevalent pediatric cancer (Pui et al., 2008; Stanulla et al., 2009). Natural products are a rich source of valuable medicinal agents. More than half of the currently available drugs are natural or related compounds. In the case of cancer therapy, the percentage of natural compound exceeds 60% (Keitaro et al., 2012). Resveratrol (trans-3, 4’, 5-trihydroxy stilbene) is produced by several plants in response to stress, injury, UV irradiation and fungal infections. Resveratrol is normally found in many dietary products such as grapes, peanuts, berries and wine (Signorelli et al., 2005). Numerous pharmacological properties have been attributed to resveratrol including antioxidant, anti-inflammatory, cardio-protective, and